Drug interactions
Cyproheptadine + Risperidone
Severity: Moderate
Cyproheptadine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so combined use may increase drowsiness and dizziness. Cyproheptadine's antiserotonergic activity may also partly oppose some effects of risperidone.
What this interaction means in plain words
Cyproheptadine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 blockade and antipsychotic activity, with additional 5-HT2 antagonism.
What to do
Monitor for oversedation and orthostatic hypotension, and review the clinical response of the psychiatric condition. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Cyproheptadine with Risperidone?
MediHelp rates the interaction as moderate. Cyproheptadine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so combined use may increase drowsiness and dizziness. Cyproheptadine's antiserotonergic activity may also partly oppose some effects of risperidone.
How serious is the interaction between Cyproheptadine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, and review the clinical response of the psychiatric condition. Counsel patients to avoid driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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