Drug interactions
Cyproheptadine + Sevoflurane
Severity: Moderate
Cyproheptadine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine may add to the CNS depressant effects of sevoflurane. This can deepen anesthesia and increase the risk of hypotension or delayed recovery.
What this interaction means in plain words
Cyproheptadine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and general anesthetic action.
What to do
Titrate sevoflurane concentration to effect with standard hemodynamic and depth-of-anesthesia monitoring. Inform the anesthesia team of cyproheptadine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Cyproheptadine with Sevoflurane?
MediHelp rates the interaction as moderate. Cyproheptadine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine may add to the CNS depressant effects of sevoflurane. This can deepen anesthesia and increase the risk of hypotension or delayed recovery.
How serious is the interaction between Cyproheptadine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane concentration to effect with standard hemodynamic and depth-of-anesthesia monitoring. Inform the anesthesia team of cyproheptadine use.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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