Drug interactions
Cyproheptadine + Stiripentol
Severity: Moderate
Cyproheptadine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence, and a sedating antihistamine can add to this effect. Patients may experience increased drowsiness, ataxia and impaired concentration.
What this interaction means in plain words
Cyproheptadine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive somnolence and adjust doses if needed. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Cyproheptadine with Stiripentol?
MediHelp rates the interaction as moderate. Cyproheptadine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence, and a sedating antihistamine can add to this effect. Patients may experience increased drowsiness, ataxia and impaired concentration.
How serious is the interaction between Cyproheptadine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive somnolence and adjust doses if needed. Advise against driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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