Drug interactions
Dabigatran + Posaconazole
Severity: Major
Dabigatran and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits P-glycoprotein and may increase absorption of dabigatran etexilate, raising plasma levels. The risk of bleeding is higher in patients with renal impairment.
What this interaction means in plain words
Dabigatran and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Posaconazole inhibits intestinal and renal P-glycoprotein efflux of dabigatran etexilate.
What to do
Avoid the combination in patients with significant renal impairment as defined in dabigatran labeling, and consider an alternative antifungal or anticoagulant. Otherwise monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dabigatran with Posaconazole?
MediHelp rates the interaction as major. Dabigatran and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole inhibits P-glycoprotein and may increase absorption of dabigatran etexilate, raising plasma levels. The risk of bleeding is higher in patients with renal impairment.
How serious is the interaction between Dabigatran and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with significant renal impairment as defined in dabigatran labeling, and consider an alternative antifungal or anticoagulant. Otherwise monitor for bleeding and renal function.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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