Drug interactions
Dabigatran + Progesterone
Severity: Moderate
Dabigatran and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone may weakly inhibit P-glycoprotein and could slightly increase dabigatran exposure, raising bleeding risk in susceptible patients. The effect is likely modest but matters in renal impairment.
What this interaction means in plain words
Dabigatran and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Progesterone may inhibit intestinal P-glycoprotein efflux of dabigatran etexilate, increasing absorption.
What to do
Monitor for bleeding and check renal function, especially if creatinine clearance is reduced. Follow dabigatran labeling on P-gp inhibitors in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Frequently asked questions
Can I take Dabigatran with Progesterone?
MediHelp rates the interaction as moderate. Dabigatran and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Progesterone may weakly inhibit P-glycoprotein and could slightly increase dabigatran exposure, raising bleeding risk in susceptible patients. The effect is likely modest but matters in renal impairment.
How serious is the interaction between Dabigatran and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check renal function, especially if creatinine clearance is reduced. Follow dabigatran labeling on P-gp inhibitors in renal impairment.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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