Drug interactions
Dabigatran + Ticlopidine
Severity: Major
Dabigatran and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs impair hemostasis through different pathways, so combined use increases the risk of bleeding, including major hemorrhage. Ticlopidine may also cause blood dyscrasias that compound the risk.
What this interaction means in plain words
Dabigatran and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect of platelet inhibition and direct thrombin inhibition.
What to do
Avoid combining unless clearly needed; if so, monitor for bleeding signs and blood counts, and review the need for dual therapy regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Dabigatran with Ticlopidine?
MediHelp rates the interaction as major. Dabigatran and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs impair hemostasis through different pathways, so combined use increases the risk of bleeding, including major hemorrhage. Ticlopidine may also cause blood dyscrasias that compound the risk.
How serious is the interaction between Dabigatran and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed; if so, monitor for bleeding signs and blood counts, and review the need for dual therapy regularly.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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