Drug interactions
Dabigatran etexilate + Erythromycin lactobionate
Severity: Moderate
Dabigatran etexilate and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits P-glycoprotein and may modestly increase dabigatran exposure. This raises the chance of bleeding, especially when kidney function is impaired, as is common in hospitalized patients.
What this interaction means in plain words
Dabigatran etexilate and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits P-glycoprotein-mediated efflux of dabigatran etexilate, increasing absorption.
What to do
Monitor for bleeding and renal function during the antibiotic course. Avoid the combination in patients with significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits P-glycoprotein and may modestly increase dabigatran exposure. This raises the chance of bleeding, especially when kidney function is impaired, as is common in hospitalized patients.
How serious is the interaction between Dabigatran etexilate and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function during the antibiotic course. Avoid the combination in patients with significant renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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