Drug interactions
Dabigatran etexilate + Fostamatinib
Severity: Moderate
Dabigatran etexilate and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may raise dabigatran concentrations. Increased exposure raises bleeding risk, particularly with renal impairment. Fostamatinib itself can also cause hypertension and affect platelet counts in ITP patients.
What this interaction means in plain words
Dabigatran etexilate and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Fostamatinib belongs to Oncology.
Why it happens
The active metabolite R406 inhibits intestinal P-glycoprotein, increasing dabigatran absorption.
What to do
Monitor for bleeding and renal function, and consider a dabigatran dose reduction if toxicity is suspected. Check platelet counts regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Fostamatinib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits P-glycoprotein and may raise dabigatran concentrations. Increased exposure raises bleeding risk, particularly with renal impairment. Fostamatinib itself can also cause hypertension and affect platelet counts in ITP patients.
How serious is the interaction between Dabigatran etexilate and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function, and consider a dabigatran dose reduction if toxicity is suspected. Check platelet counts regularly.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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