Drug interactions
Dabigatran etexilate + Lopinavir
Severity: Major
Dabigatran etexilate and Lopinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir inhibits P-glycoprotein and may raise dabigatran exposure, increasing bleeding risk. Ritonavir can also have complex inhibitory and inductive effects on transporters.
What this interaction means in plain words
Dabigatran etexilate and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Lopinavir belongs to Anti Virals.
Why it happens
Inhibition of intestinal P-glycoprotein increases dabigatran etexilate bioavailability.
What to do
Avoid in patients with renal impairment; otherwise monitor closely for bleeding. Consider an alternative anticoagulant during HIV protease inhibitor therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Lopinavir?
MediHelp rates the interaction as major. Dabigatran etexilate and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted lopinavir inhibits P-glycoprotein and may raise dabigatran exposure, increasing bleeding risk. Ritonavir can also have complex inhibitory and inductive effects on transporters.
How serious is the interaction between Dabigatran etexilate and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with renal impairment; otherwise monitor closely for bleeding. Consider an alternative anticoagulant during HIV protease inhibitor therapy.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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