Drug interactions
Dabigatran etexilate + Pretomanid
Severity: Moderate
Dabigatran etexilate and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid has been shown to inhibit P-glycoprotein in vitro, so it may raise dabigatran concentrations. The clinical effect has not been well characterized.
What this interaction means in plain words
Dabigatran etexilate and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Pretomanid is predicted to inhibit P-glycoprotein, reducing efflux of dabigatran etexilate and increasing exposure.
What to do
Monitor for bleeding and renal function during co-therapy. Avoid the combination if creatinine clearance is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabigatran etexilate and Pretomanid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Dabigatran etexilate with Pretomanid?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid has been shown to inhibit P-glycoprotein in vitro, so it may raise dabigatran concentrations. The clinical effect has not been well characterized.
How serious is the interaction between Dabigatran etexilate and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function during co-therapy. Avoid the combination if creatinine clearance is reduced.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
