Drug interactions
Dabigatran etexilate + Ranolazine
Severity: Moderate
Dabigatran etexilate and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak P-glycoprotein inhibitor and may modestly increase dabigatran exposure. This could raise bleeding risk, particularly in patients with impaired renal function.
What this interaction means in plain words
Dabigatran etexilate and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine inhibits intestinal P-glycoprotein, reducing efflux of dabigatran etexilate and increasing its absorption.
What to do
Monitor for bleeding and check renal function before and during combined therapy. Avoid the combination if creatinine clearance is markedly reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Ranolazine?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine is a weak P-glycoprotein inhibitor and may modestly increase dabigatran exposure. This could raise bleeding risk, particularly in patients with impaired renal function.
How serious is the interaction between Dabigatran etexilate and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check renal function before and during combined therapy. Avoid the combination if creatinine clearance is markedly reduced.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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