Drug interactions
Dabigatran etexilate + Stiripentol
Severity: Moderate
Dabigatran etexilate and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol may inhibit P-glycoprotein and so increase absorption of dabigatran etexilate, leading to higher dabigatran concentrations. This could increase bleeding risk, especially with renal impairment.
What this interaction means in plain words
Dabigatran etexilate and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases dabigatran etexilate absorption.
What to do
Monitor for bleeding and renal function when starting or stopping stiripentol. Consider lowering the dabigatran dose or using an alternative anticoagulant if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Dabigatran etexilate with Stiripentol?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol may inhibit P-glycoprotein and so increase absorption of dabigatran etexilate, leading to higher dabigatran concentrations. This could increase bleeding risk, especially with renal impairment.
How serious is the interaction between Dabigatran etexilate and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function when starting or stopping stiripentol. Consider lowering the dabigatran dose or using an alternative anticoagulant if bleeding occurs.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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