Drug interactions
Dabrafenib + Enzalutamide
Severity: Major
Dabrafenib and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 and CYP2C8 inducers and substrates, so each may lower the other's exposure. This may reduce the efficacy of both the melanoma and prostate cancer treatments.
What this interaction means in plain words
Dabrafenib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Mutual induction of CYP3A4 and CYP2C8 increases the metabolic clearance of both drugs.
What to do
Avoid the combination where possible. If used together, monitor tumor response for both diseases closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Enzalutamide?
MediHelp rates the interaction as major. Dabrafenib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are CYP3A4 and CYP2C8 inducers and substrates, so each may lower the other's exposure. This may reduce the efficacy of both the melanoma and prostate cancer treatments.
How serious is the interaction between Dabrafenib and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor tumor response for both diseases closely.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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