Drug interactions
Dabrafenib + Fenofibric acid
Severity: Minor
Dabrafenib and Fenofibric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes, but fenofibric acid is cleared mainly by glucuronidation and renal excretion rather than CYP3A4. A meaningful loss of lipid-lowering effect is therefore unlikely.
What this interaction means in plain words
Dabrafenib and Fenofibric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Fenofibric acid belongs to Cardiovascular.
Why it happens
Enzyme induction by dabrafenib is predicted, but CYP3A4 plays only a minor role in fenofibric acid clearance.
What to do
No dose change is needed; check the lipid profile at routine intervals during dabrafenib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Fenofibric acid?
MediHelp rates the interaction as minor. Dabrafenib and Fenofibric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes, but fenofibric acid is cleared mainly by glucuronidation and renal excretion rather than CYP3A4. A meaningful loss of lipid-lowering effect is therefore unlikely.
How serious is the interaction between Dabrafenib and Fenofibric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; check the lipid profile at routine intervals during dabrafenib therapy.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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