Drug interactions
Dabrafenib + Medroxyprogesterone
Severity: Moderate
Dabrafenib and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce medroxyprogesterone concentrations, risking reduced contraceptive or therapeutic effect.
What this interaction means in plain words
Dabrafenib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4, increasing medroxyprogesterone metabolism.
What to do
Advise an effective non-hormonal contraceptive method and monitor for loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Medroxyprogesterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Medroxyprogesterone
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Dabrafenib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may reduce medroxyprogesterone concentrations, risking reduced contraceptive or therapeutic effect.
How serious is the interaction between Dabrafenib and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an effective non-hormonal contraceptive method and monitor for loss of efficacy.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
