Drug interactions
Dabrafenib + Posaconazole
Severity: Major
Dabrafenib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase dabrafenib levels, potentially worsening toxicities such as fever, rash, hyperglycemia and QT effects. Dabrafenib in turn is a CYP3A4 inducer and may lower posaconazole exposure, risking reduced antifungal efficacy.
What this interaction means in plain words
Dabrafenib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 (and P-gp), raising dabrafenib; dabrafenib induces CYP3A4 and may lower posaconazole levels.
What to do
Use an alternative antifungal where possible. If both are required, monitor for dabrafenib toxicity and consider posaconazole therapeutic drug monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Posaconazole?
MediHelp rates the interaction as major. Dabrafenib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can increase dabrafenib levels, potentially worsening toxicities such as fever, rash, hyperglycemia and QT effects. Dabrafenib in turn is a CYP3A4 inducer and may lower posaconazole exposure, risking reduced antifungal efficacy.
How serious is the interaction between Dabrafenib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antifungal where possible. If both are required, monitor for dabrafenib toxicity and consider posaconazole therapeutic drug monitoring.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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