Drug interactions
Dabrafenib + Progesterone
Severity: Moderate
Dabrafenib and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may reduce progesterone concentrations. Reduced hormonal effect, including contraceptive failure, may result.
What this interaction means in plain words
Dabrafenib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4, increasing progesterone metabolism.
What to do
Monitor for reduced progestogenic effect and adjust the dose if needed. Advise an effective non-hormonal contraceptive method during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Progesterone?
MediHelp rates the interaction as moderate. Dabrafenib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may reduce progesterone concentrations. Reduced hormonal effect, including contraceptive failure, may result.
How serious is the interaction between Dabrafenib and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progestogenic effect and adjust the dose if needed. Advise an effective non-hormonal contraceptive method during treatment.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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