Drug interactions
Dabrafenib + Ticlopidine
Severity: Minor
Dabrafenib and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C enzymes and may lower concentrations of co-administered drugs. Ticlopidine is not a sensitive CYP3A4 substrate, so any reduction in effect is uncertain.
What this interaction means in plain words
Dabrafenib and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible enzyme induction by dabrafenib reducing ticlopidine exposure; not well characterized.
What to do
Monitor for reduced antiplatelet effect and clinical outcomes; no routine dose change is recommended.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ticlopidine?
MediHelp rates the interaction as minor. Dabrafenib and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and CYP2C enzymes and may lower concentrations of co-administered drugs. Ticlopidine is not a sensitive CYP3A4 substrate, so any reduction in effect is uncertain.
How serious is the interaction between Dabrafenib and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiplatelet effect and clinical outcomes; no routine dose change is recommended.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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