Drug interactions
Dacarbazine + Teriflunomide
Severity: Minor
Dacarbazine and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide weakly induces CYP1A2, which contributes to the activation of dacarbazine. Exposure to its active metabolite could change slightly, but the clinical effect is uncertain and probably small.
What this interaction means in plain words
Dacarbazine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacarbazine belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak CYP1A2 induction by teriflunomide may alter the metabolic activation of dacarbazine.
What to do
No dose change is needed routinely; monitor the response to dacarbazine and its toxicity during the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Teriflunomide?
MediHelp rates the interaction as minor. Dacarbazine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide weakly induces CYP1A2, which contributes to the activation of dacarbazine. Exposure to its active metabolite could change slightly, but the clinical effect is uncertain and probably small.
How serious is the interaction between Dacarbazine and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely; monitor the response to dacarbazine and its toxicity during the combination.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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