Drug interactions
Dacomitinib + Dutasteride-tamsulosin
Severity: Moderate
Dacomitinib and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and can increase tamsulosin exposure, since CYP2D6 contributes to tamsulosin clearance. This may cause orthostatic hypotension and dizziness.
What this interaction means in plain words
Dacomitinib and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Dacomitinib inhibits CYP2D6, reducing tamsulosin metabolism.
What to do
Monitor blood pressure and orthostatic symptoms and reduce tamsulosin dose or switch if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Dacomitinib and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and can increase tamsulosin exposure, since CYP2D6 contributes to tamsulosin clearance. This may cause orthostatic hypotension and dizziness.
How serious is the interaction between Dacomitinib and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms and reduce tamsulosin dose or switch if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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