Drug interactions
Dacomitinib + Fluoxetine
Severity: Minor
Dacomitinib and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor. Fluoxetine is a CYP2D6 substrate but is also a strong CYP2D6 inhibitor itself, so the rise in fluoxetine exposure is likely small, and fluoxetine has a wide therapeutic margin. The clinical effect is generally limited to modestly increased fluoxetine adverse effects.
What this interaction means in plain words
Dacomitinib and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacomitinib belongs to Oncology; Fluoxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by dacomitinib reduces fluoxetine metabolism.
What to do
No routine dose change is needed. Monitor for increased fluoxetine adverse effects such as nausea, agitation or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Fluoxetine?
MediHelp rates the interaction as minor. Dacomitinib and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib is a strong CYP2D6 inhibitor. Fluoxetine is a CYP2D6 substrate but is also a strong CYP2D6 inhibitor itself, so the rise in fluoxetine exposure is likely small, and fluoxetine has a wide therapeutic margin. The clinical effect is generally limited to modestly increased fluoxetine adverse effects.
How serious is the interaction between Dacomitinib and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased fluoxetine adverse effects such as nausea, agitation or insomnia.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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