Drug interactions
Dacomitinib + Nebivolol
Severity: Moderate
Dacomitinib and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise exposure to nebivolol, which depends on CYP2D6 for clearance. This may cause excessive bradycardia and hypotension.
What this interaction means in plain words
Dacomitinib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism by dacomitinib.
What to do
Monitor heart rate and blood pressure and lower the nebivolol dose if bradycardia or hypotension develops. Consider an alternative beta-blocker not cleared by CYP2D6 if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Nebivolol?
MediHelp rates the interaction as moderate. Dacomitinib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise exposure to nebivolol, which depends on CYP2D6 for clearance. This may cause excessive bradycardia and hypotension.
How serious is the interaction between Dacomitinib and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and lower the nebivolol dose if bradycardia or hypotension develops. Consider an alternative beta-blocker not cleared by CYP2D6 if needed.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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