Drug interactions
Dacomitinib + Propafenone
Severity: Major
Dacomitinib and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong inhibitor of CYP2D6, the main enzyme that converts propafenone to its 5-hydroxy metabolite. Propafenone concentrations may rise substantially, increasing the risk of proarrhythmia, conduction disturbances and CNS or other dose-related adverse effects.
What this interaction means in plain words
Dacomitinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Dacomitinib inhibits CYP2D6, reducing propafenone clearance.
What to do
Avoid the combination where possible and consider an alternative antiarrhythmic. If it cannot be avoided, use a reduced propafenone dose with ECG monitoring for PR/QRS widening and arrhythmia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Propafenone?
MediHelp rates the interaction as major. Dacomitinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong inhibitor of CYP2D6, the main enzyme that converts propafenone to its 5-hydroxy metabolite. Propafenone concentrations may rise substantially, increasing the risk of proarrhythmia, conduction disturbances and CNS or other dose-related adverse effects.
How serious is the interaction between Dacomitinib and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider an alternative antiarrhythmic. If it cannot be avoided, use a reduced propafenone dose with ECG monitoring for PR/QRS widening and arrhythmia.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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