Drug interactions
Dacomitinib + Sertraline
Severity: Minor
Dacomitinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which can raise sertraline exposure somewhat. Sertraline is cleared by several enzymes, so the effect is usually modest and mainly shows up as more serotonergic or gastrointestinal adverse effects.
What this interaction means in plain words
Dacomitinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacomitinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Dacomitinib inhibits CYP2D6, which reduces one pathway of sertraline metabolism.
What to do
No routine dose change is needed. Monitor for increased sertraline adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Sertraline?
MediHelp rates the interaction as minor. Dacomitinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib strongly inhibits CYP2D6, which can raise sertraline exposure somewhat. Sertraline is cleared by several enzymes, so the effect is usually modest and mainly shows up as more serotonergic or gastrointestinal adverse effects.
How serious is the interaction between Dacomitinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased sertraline adverse effects and reduce the dose if they occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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