Drug interactions
Dacomitinib + Tamsulosin
Severity: Moderate
Dacomitinib and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which contributes to tamsulosin metabolism, so tamsulosin exposure may increase. This can cause hypotension and dizziness.
What this interaction means in plain words
Dacomitinib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by dacomitinib reduces tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the tamsulosin dose or switch if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Tamsulosin?
MediHelp rates the interaction as moderate. Dacomitinib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, which contributes to tamsulosin metabolism, so tamsulosin exposure may increase. This can cause hypotension and dizziness.
How serious is the interaction between Dacomitinib and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the tamsulosin dose or switch if symptomatic.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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