Drug interactions
Dactinomycin + Liposomal doxorubicin
Severity: Moderate
Dactinomycin and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin and dactinomycin can both sensitize tissues to radiation, and radiation recall reactions, including pneumonitis, have been described when they are given close to radiotherapy. Additive myelosuppression and cardiotoxicity are also possible with anthracycline-containing regimens.
What this interaction means in plain words
Dactinomycin and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Additive radiosensitizing and cytotoxic effects of both agents on irradiated and normal tissue.
What to do
Avoid giving the combination close to radiotherapy where possible, and monitor for pulmonary symptoms and radiation recall. Monitor blood counts and cardiac function during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Frequently asked questions
Can I take Dactinomycin with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Dactinomycin and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxorubicin and dactinomycin can both sensitize tissues to radiation, and radiation recall reactions, including pneumonitis, have been described when they are given close to radiotherapy. Additive myelosuppression and cardiotoxicity are also possible with anthracycline-containing regimens.
How serious is the interaction between Dactinomycin and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the combination close to radiotherapy where possible, and monitor for pulmonary symptoms and radiation recall. Monitor blood counts and cardiac function during treatment.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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