Drug interactions
Dactinomycin + Trastuzumab deruxtecan
Severity: Moderate
Dactinomycin and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and dactinomycin is itself myelosuppressive. Combining them raises the risk of severe neutropenia, febrile neutropenia and infection.
What this interaction means in plain words
Dactinomycin and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload of trastuzumab deruxtecan and dactinomycin.
What to do
Check neutrophil counts before each dose and regularly during treatment. Interrupt or reduce doses for grade 3 or higher neutropenia, and give supportive care such as growth factors where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Dactinomycin with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Dactinomycin and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and dactinomycin is itself myelosuppressive. Combining them raises the risk of severe neutropenia, febrile neutropenia and infection.
How serious is the interaction between Dactinomycin and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check neutrophil counts before each dose and regularly during treatment. Interrupt or reduce doses for grade 3 or higher neutropenia, and give supportive care such as growth factors where appropriate.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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