Drug interactions
Dalteparin + Diclofenac
Severity: Major
Dalteparin and Diclofenac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac inhibits platelet function and can cause GI ulceration, and dalteparin is an anticoagulant. Using both raises the risk of clinically important bleeding.
What this interaction means in plain words
Dalteparin and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis from NSAID platelet inhibition and low molecular weight heparin anti-Xa activity.
What to do
Avoid concomitant NSAIDs where possible; if needed, use the lowest dose for the shortest time and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Diclofenac?
MediHelp rates the interaction as major. Dalteparin and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac inhibits platelet function and can cause GI ulceration, and dalteparin is an anticoagulant. Using both raises the risk of clinically important bleeding.
How serious is the interaction between Dalteparin and Diclofenac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant NSAIDs where possible; if needed, use the lowest dose for the shortest time and monitor for bleeding and hemoglobin.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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