Drug interactions
Dalteparin + Diflunisal
Severity: Major
Dalteparin and Diflunisal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal inhibits platelet function and can injure the gastric mucosa, so it increases bleeding when combined with a low molecular weight heparin. Serious hemorrhage, including GI bleeding, is possible.
What this interaction means in plain words
Dalteparin and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: NSAID antiplatelet effect and mucosal injury combined with heparin-mediated anticoagulation.
What to do
Avoid concurrent use when possible and choose a non-NSAID analgesic such as paracetamol. If combined, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Diflunisal?
MediHelp rates the interaction as major. Dalteparin and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diflunisal inhibits platelet function and can injure the gastric mucosa, so it increases bleeding when combined with a low molecular weight heparin. Serious hemorrhage, including GI bleeding, is possible.
How serious is the interaction between Dalteparin and Diflunisal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible and choose a non-NSAID analgesic such as paracetamol. If combined, monitor for bleeding and hemoglobin.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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