Drug interactions
Dalteparin + Etodolac
Severity: Major
Dalteparin and Etodolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac inhibits platelet function and can cause GI ulceration, so when given with dalteparin the risk of bleeding is higher. Spinal or epidural hematoma risk is also increased with neuraxial procedures.
What this interaction means in plain words
Dalteparin and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis: NSAID platelet inhibition plus low molecular weight heparin anti-Xa activity.
What to do
Avoid the combination where possible and use a non-NSAID analgesic. If unavoidable, monitor hemoglobin and for bleeding, and follow neuraxial anesthesia precautions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Etodolac?
MediHelp rates the interaction as major. Dalteparin and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac inhibits platelet function and can cause GI ulceration, so when given with dalteparin the risk of bleeding is higher. Spinal or epidural hematoma risk is also increased with neuraxial procedures.
How serious is the interaction between Dalteparin and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-NSAID analgesic. If unavoidable, monitor hemoglobin and for bleeding, and follow neuraxial anesthesia precautions.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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