Drug interactions
Dalteparin + Hydrochlorothiazide-losartan
Severity: Moderate
Dalteparin and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins including low molecular weight heparins can suppress aldosterone secretion and cause hyperkalemia, which adds to the potassium-retaining effect of losartan. The risk is highest in renal impairment, diabetes and with prolonged use; the thiazide partly counteracts it.
What this interaction means in plain words
Dalteparin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis combined with angiotensin receptor blockade increases potassium retention.
What to do
Monitor serum potassium and renal function, particularly if dalteparin is used for more than a few days. Adjust therapy if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Dalteparin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins including low molecular weight heparins can suppress aldosterone secretion and cause hyperkalemia, which adds to the potassium-retaining effect of losartan. The risk is highest in renal impairment, diabetes and with prolonged use; the thiazide partly counteracts it.
How serious is the interaction between Dalteparin and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly if dalteparin is used for more than a few days. Adjust therapy if hyperkalemia develops.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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