Drug interactions
Dalteparin + Imatinib
Severity: Moderate
Dalteparin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and occasionally hemorrhage, so adding a therapeutic-dose anticoagulant may raise the bleeding risk. Low-molecular-weight heparin is preferred over warfarin in patients on imatinib because of imatinib's effect on warfarin metabolism.
What this interaction means in plain words
Dalteparin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Additive bleeding risk from imatinib-related thrombocytopenia and platelet dysfunction together with anticoagulation by dalteparin.
What to do
Monitor platelet counts and watch for bleeding during combined use. Reduce or hold dalteparin if significant thrombocytopenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dalteparin and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dalteparin with Imatinib?
MediHelp rates the interaction as moderate. Dalteparin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and occasionally hemorrhage, so adding a therapeutic-dose anticoagulant may raise the bleeding risk. Low-molecular-weight heparin is preferred over warfarin in patients on imatinib because of imatinib's effect on warfarin metabolism.
How serious is the interaction between Dalteparin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and watch for bleeding during combined use. Reduce or hold dalteparin if significant thrombocytopenia occurs.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
