Drug interactions
Dalteparin + Indomethacin
Severity: Major
Dalteparin and Indomethacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin impairs platelet function and irritates the gastric mucosa, raising the risk of bleeding in patients receiving low molecular weight heparin. Gastrointestinal and other hemorrhages may occur.
What this interaction means in plain words
Dalteparin and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive impairment of hemostasis: antiplatelet effect of NSAID plus factor Xa inhibition by dalteparin.
What to do
Avoid combined use where possible; otherwise monitor for bleeding, hemoglobin and renal function, and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Indomethacin?
MediHelp rates the interaction as major. Dalteparin and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin impairs platelet function and irritates the gastric mucosa, raising the risk of bleeding in patients receiving low molecular weight heparin. Gastrointestinal and other hemorrhages may occur.
How serious is the interaction between Dalteparin and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; otherwise monitor for bleeding, hemoglobin and renal function, and consider gastroprotection.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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