Drug interactions
Dalteparin + Ketoprofen
Severity: Major
Dalteparin and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases the risk of bleeding, especially gastrointestinal bleeding, because the NSAID impairs platelet function and damages mucosa while the heparin impairs clotting. Labeling advises caution with agents affecting hemostasis.
What this interaction means in plain words
Dalteparin and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive effect of antithrombin-mediated anticoagulation with NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid the combination if possible and choose paracetamol for analgesia; if needed, monitor for bleeding and hemoglobin closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Ketoprofen?
MediHelp rates the interaction as major. Dalteparin and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use increases the risk of bleeding, especially gastrointestinal bleeding, because the NSAID impairs platelet function and damages mucosa while the heparin impairs clotting. Labeling advises caution with agents affecting hemostasis.
How serious is the interaction between Dalteparin and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose paracetamol for analgesia; if needed, monitor for bleeding and hemoglobin closely.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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