Drug interactions
Dalteparin + Oxaprozin
Severity: Major
Dalteparin and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dalteparin anticoagulation combined with NSAID-induced platelet dysfunction and gastric mucosal injury increases the likelihood of serious bleeding. Gastrointestinal hemorrhage is the main concern.
What this interaction means in plain words
Dalteparin and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: low molecular weight heparin potentiates antithrombin while the NSAID inhibits platelet function and damages the gastric mucosa.
What to do
Avoid concurrent NSAID use if possible, preferring acetaminophen for analgesia. If co-administered, monitor hemoglobin and for signs of bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Oxaprozin?
MediHelp rates the interaction as major. Dalteparin and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dalteparin anticoagulation combined with NSAID-induced platelet dysfunction and gastric mucosal injury increases the likelihood of serious bleeding. Gastrointestinal hemorrhage is the main concern.
How serious is the interaction between Dalteparin and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use if possible, preferring acetaminophen for analgesia. If co-administered, monitor hemoglobin and for signs of bleeding and consider gastroprotection.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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