Drug interactions
Dalteparin + Ticagrelor
Severity: Moderate
Dalteparin and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a low molecular weight heparin with a potent P2Y12 platelet inhibitor increases the likelihood of bleeding, including gastrointestinal and procedural bleeding. The pairing is often intentional in acute coronary syndromes, but the bleeding risk is still higher than with either drug alone.
What this interaction means in plain words
Dalteparin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: dalteparin potentiates antithrombin-mediated inhibition of factor Xa while ticagrelor blocks ADP-induced platelet aggregation.
What to do
Use only when both agents are clearly indicated, and limit the duration of overlap. Monitor for bleeding signs and track hemoglobin and platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Dalteparin with Ticagrelor?
MediHelp rates the interaction as moderate. Dalteparin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a low molecular weight heparin with a potent P2Y12 platelet inhibitor increases the likelihood of bleeding, including gastrointestinal and procedural bleeding. The pairing is often intentional in acute coronary syndromes, but the bleeding risk is still higher than with either drug alone.
How serious is the interaction between Dalteparin and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when both agents are clearly indicated, and limit the duration of overlap. Monitor for bleeding signs and track hemoglobin and platelet counts.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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