Drug interactions
Danazol + Enzalutamide
Severity: Moderate
Danazol and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and might slightly increase enzalutamide exposure. Danazol also has androgenic activity that opposes the intended therapy in prostate cancer.
What this interaction means in plain words
Danazol and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol weakly inhibits CYP3A4, and as an androgenic agent it counteracts androgen receptor blockade.
What to do
Avoid danazol in patients with prostate cancer when possible. If it must be used, monitor PSA and enzalutamide adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Danazol with Enzalutamide?
MediHelp rates the interaction as moderate. Danazol and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak CYP3A4 inhibitor and might slightly increase enzalutamide exposure. Danazol also has androgenic activity that opposes the intended therapy in prostate cancer.
How serious is the interaction between Danazol and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid danazol in patients with prostate cancer when possible. If it must be used, monitor PSA and enzalutamide adverse effects.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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