Drug interactions
Danazol + Medroxyprogesterone
Severity: Minor
Danazol and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and could slightly raise medroxyprogesterone levels. It also has opposing hormonal activity, but a meaningful kinetic interaction is unlikely.
What this interaction means in plain words
Danazol and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by danazol may reduce progestin metabolism.
What to do
No specific action beyond awareness; monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Danazol with Medroxyprogesterone?
MediHelp rates the interaction as minor. Danazol and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and could slightly raise medroxyprogesterone levels. It also has opposing hormonal activity, but a meaningful kinetic interaction is unlikely.
How serious is the interaction between Danazol and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond awareness; monitor for progestogenic adverse effects.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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