Drug interactions
Danazol + Ticlopidine
Severity: Minor
Danazol and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and could modestly raise ticlopidine concentrations. Ticlopidine is metabolised by several pathways, so the effect is probably small, but ticlopidine toxicity includes neutropenia and thrombocytopenia. Danazol itself can also affect clotting and platelets.
What this interaction means in plain words
Danazol and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4, which contributes to ticlopidine metabolism.
What to do
Monitor complete blood counts as already required during ticlopidine therapy and watch for bleeding or bruising.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Danazol with Ticlopidine?
MediHelp rates the interaction as minor. Danazol and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak to moderate CYP3A4 inhibitor and could modestly raise ticlopidine concentrations. Ticlopidine is metabolised by several pathways, so the effect is probably small, but ticlopidine toxicity includes neutropenia and thrombocytopenia. Danazol itself can also affect clotting and platelets.
How serious is the interaction between Danazol and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts as already required during ticlopidine therapy and watch for bleeding or bruising.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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