Drug interactions
Danicopan + Desogestrel-ethinyl estradiol
Severity: Minor
Danicopan and Desogestrel-ethinyl estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and may increase exposure to BCRP substrates. Ethinyl estradiol exposure might rise modestly, with possible increased estrogenic effects.
What this interaction means in plain words
Danicopan and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Inhibition of intestinal BCRP efflux by danicopan increases absorption of substrates.
What to do
Monitor for estrogenic adverse effects such as nausea and breast tenderness; no routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as minor. Danicopan and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits BCRP and may increase exposure to BCRP substrates. Ethinyl estradiol exposure might rise modestly, with possible increased estrogenic effects.
How serious is the interaction between Danicopan and Desogestrel-ethinyl estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as nausea and breast tenderness; no routine dose change is required.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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