Drug interactions
Danicopan + Dipyridamole
Severity: Moderate
Danicopan and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and may raise plasma concentrations of BCRP substrates such as dipyridamole. This may increase dipyridamole effects, including hypotension, headache and bleeding tendency.
What this interaction means in plain words
Danicopan and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Dipyridamole belongs to Cardiovascular.
Why it happens
Inhibition of intestinal BCRP by danicopan increases dipyridamole absorption and exposure.
What to do
Monitor for increased dipyridamole effects such as hypotension and headache, and consider reducing the dipyridamole dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Dipyridamole?
MediHelp rates the interaction as moderate. Danicopan and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and may raise plasma concentrations of BCRP substrates such as dipyridamole. This may increase dipyridamole effects, including hypotension, headache and bleeding tendency.
How serious is the interaction between Danicopan and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased dipyridamole effects such as hypotension and headache, and consider reducing the dipyridamole dose if they occur.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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