Drug interactions
Danicopan + Erythromycin
Severity: Moderate
Danicopan and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates. Erythromycin is a P-gp substrate, so its exposure may increase, with greater risk of dose-related adverse effects including QT prolongation.
What this interaction means in plain words
Danicopan and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
P-glycoprotein inhibition by danicopan decreases erythromycin efflux.
What to do
Monitor for erythromycin adverse effects such as gastrointestinal intolerance and QT prolongation. Consider an alternative antibiotic if the patient has QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Erythromycin?
MediHelp rates the interaction as moderate. Danicopan and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates. Erythromycin is a P-gp substrate, so its exposure may increase, with greater risk of dose-related adverse effects including QT prolongation.
How serious is the interaction between Danicopan and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin adverse effects such as gastrointestinal intolerance and QT prolongation. Consider an alternative antibiotic if the patient has QT risk factors.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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