Drug interactions
Danicopan + Fluvastatin
Severity: Moderate
Danicopan and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and raises exposure to BCRP substrates. Fluvastatin is partly handled by BCRP, so its concentrations may increase and raise the risk of muscle toxicity.
What this interaction means in plain words
Danicopan and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Fluvastatin belongs to Cardiovascular.
Why it happens
Danicopan inhibits BCRP, reducing fluvastatin efflux and increasing exposure.
What to do
Monitor for myopathy and consider limiting the fluvastatin dose. Check creatine kinase if muscle symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Fluvastatin?
MediHelp rates the interaction as moderate. Danicopan and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and raises exposure to BCRP substrates. Fluvastatin is partly handled by BCRP, so its concentrations may increase and raise the risk of muscle toxicity.
How serious is the interaction between Danicopan and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy and consider limiting the fluvastatin dose. Check creatine kinase if muscle symptoms appear.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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