Drug interactions
Danicopan + Glyburide-metformin
Severity: Moderate
Danicopan and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan increases exposure to BCRP substrates, and glyburide is one of them. Higher glyburide levels may cause hypoglycemia.
What this interaction means in plain words
Danicopan and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Danicopan inhibits BCRP, reducing efflux and increasing concentrations of glyburide.
What to do
Monitor blood glucose and consider lowering the glyburide dose when danicopan is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Glyburide-metformin?
MediHelp rates the interaction as moderate. Danicopan and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan increases exposure to BCRP substrates, and glyburide is one of them. Higher glyburide levels may cause hypoglycemia.
How serious is the interaction between Danicopan and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider lowering the glyburide dose when danicopan is started.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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