Drug interactions
Danicopan + Irinotecan
Severity: Moderate
Danicopan and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and BCRP, which can increase exposure to irinotecan and SN-38. This may worsen diarrhea and myelosuppression.
What this interaction means in plain words
Danicopan and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Irinotecan belongs to Oncology.
Why it happens
Danicopan inhibits P-gp and BCRP efflux transporters.
What to do
Monitor blood counts and diarrhea, and consider lowering the irinotecan dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Irinotecan?
MediHelp rates the interaction as moderate. Danicopan and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and BCRP, which can increase exposure to irinotecan and SN-38. This may worsen diarrhea and myelosuppression.
How serious is the interaction between Danicopan and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea, and consider lowering the irinotecan dose if adverse effects occur.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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