Drug interactions
Danicopan + Ledipasvir-sofosbuvir
Severity: Moderate
Danicopan and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP, both of which transport ledipasvir and sofosbuvir. Antiviral exposure may rise, though the expected clinical effect is limited.
What this interaction means in plain words
Danicopan and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Danicopan inhibits intestinal P-gp and BCRP efflux of ledipasvir and sofosbuvir.
What to do
Monitor for antiviral adverse effects such as headache and fatigue; no routine dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Danicopan and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and BCRP, both of which transport ledipasvir and sofosbuvir. Antiviral exposure may rise, though the expected clinical effect is limited.
How serious is the interaction between Danicopan and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antiviral adverse effects such as headache and fatigue; no routine dose change is required.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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