Drug interactions
Danicopan + Morphine
Severity: Moderate
Danicopan and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase morphine exposure, potentially intensifying sedation and respiratory depression.
What this interaction means in plain words
Danicopan and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Morphine belongs to Musculoskeletal.
Why it happens
P-glycoprotein inhibition reduces efflux of morphine.
What to do
Monitor for opioid excess and consider a lower morphine dose when starting danicopan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Morphine?
MediHelp rates the interaction as moderate. Danicopan and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase morphine exposure, potentially intensifying sedation and respiratory depression.
How serious is the interaction between Danicopan and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for opioid excess and consider a lower morphine dose when starting danicopan.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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