Drug interactions
Danicopan + Pantoprazole
Severity: Minor
Danicopan and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP, and pantoprazole is a BCRP substrate, so pantoprazole exposure may increase. The effect is expected to be modest given the wide safety margin of pantoprazole.
What this interaction means in plain words
Danicopan and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Danicopan inhibition of BCRP efflux increases pantoprazole absorption.
What to do
No routine adjustment is required. Monitor for pantoprazole adverse effects with high doses or long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Pantoprazole?
MediHelp rates the interaction as minor. Danicopan and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits BCRP, and pantoprazole is a BCRP substrate, so pantoprazole exposure may increase. The effect is expected to be modest given the wide safety margin of pantoprazole.
How serious is the interaction between Danicopan and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor for pantoprazole adverse effects with high doses or long-term use.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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