Drug interactions
Danicopan + Pazopanib
Severity: Moderate
Danicopan and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP, and pazopanib is a substrate of both transporters, so its exposure may rise. This may increase pazopanib toxicities including hepatotoxicity.
What this interaction means in plain words
Danicopan and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Inhibition of intestinal P-gp and BCRP efflux by danicopan increases pazopanib absorption.
What to do
Monitor liver enzymes and blood pressure, and consider reducing pazopanib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Pazopanib?
MediHelp rates the interaction as moderate. Danicopan and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and BCRP, and pazopanib is a substrate of both transporters, so its exposure may rise. This may increase pazopanib toxicities including hepatotoxicity.
How serious is the interaction between Danicopan and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood pressure, and consider reducing pazopanib dose if adverse effects occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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