Drug interactions
Danicopan + Quinine
Severity: Moderate
Danicopan and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can increase exposure to P-gp substrates such as quinine. Quinine has a narrow therapeutic window, so higher levels may cause cinchonism, QT prolongation or hypoglycemia.
What this interaction means in plain words
Danicopan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Quinine belongs to Anti Parasitic.
Why it happens
Danicopan inhibits intestinal P-glycoprotein efflux, increasing quinine absorption and exposure.
What to do
Monitor for quinine toxicity such as tinnitus, dizziness and QT prolongation, and consider ECG monitoring. Reduce the quinine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Quinine?
MediHelp rates the interaction as moderate. Danicopan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can increase exposure to P-gp substrates such as quinine. Quinine has a narrow therapeutic window, so higher levels may cause cinchonism, QT prolongation or hypoglycemia.
How serious is the interaction between Danicopan and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as tinnitus, dizziness and QT prolongation, and consider ECG monitoring. Reduce the quinine dose if adverse effects appear.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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